Ongoing Protocols
All clinical trials done by the HVTN test the safety of vaccine or mAb candidates. We also look at tolerability to see if people have side effects that make them very uncomfortable. We look at the immune responses that are generated in people who receive these vaccines. Our efficacy studies look at whether a vaccine or antibody protects against HIV, or control HIV if infection does occur.
Many of these trials test combinations of products in various doses, schedules, and sequences. For example, does a DNA vaccine followed by a viral vector vaccine generate a different immune response than the same regimen in the reverse order? We may also look at different ways of administering the vaccines, such as using a needle and syringe or needle-free devices.